Article
Dynamic monitoring of circulating tumor DNA to predict prognosis and efficacy of adjuvant chemotherapy after resection of colorectal liver metastases.
Theranostics - 1 Jan 2021
Wang De-Shen, Yang Hui, Liu Xiao-Yun, Chen Zhi-Gang, Wang Yun, Fong William Pat, Hu Ming-Tao, Zheng Yuan-Chao, Zheng Yun, Li Bin-Kui, Yuan Yun-Fei, Chen Gong, Pan Zhi-Zhong, Song Lele, Li Yu-Hong, Xu Rui-Hua
Abstract excerpt
Rationale: Hepatectomy and adjuvant chemotherapy after resection of colorectal liver metastases (CRLM) may improve survival, however, patients which may benefit cannot currently be identified. Postoperative circulating tumor DNA (ctDNA) analysis can detect minimal residual disease (MRD) and predict the prognosis and efficacy of adjuvant chemotherapy. Our study aims to determine the impact of serial ctDNA analysis...
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