Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: a prospective biomarker study.

doi:10.1136/gutjnl-2017-315852

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Article

Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: a prospective biomarker study.

Gut - 1 Apr 2019

Tie Jeanne, Cohen Joshua D, Wang Yuxuan, Li Lu, Christie Michael, Simons Koen, Elsaleh Hany, Kosmider Suzanne, Wong Rachel, Yip Desmond, Lee Margaret, Tran Ben, Rangiah David, Burge Matthew, Goldstein David, Singh Madhu, Skinner Iain, Faragher Ian, Croxford Matthew, Bampton Carolyn, Haydon Andrew, Jones Ian T, S Karapetis Christos, Price Timothy, Schaefer Mary J, Ptak Jeanne, Dobbyn Lisa, Silliman Natallie, Kinde Isaac, Tomasetti Cristian, Papadopoulos Nickolas, Kinzler Kenneth, Volgestein Bert, Gibbs Peter

Abstract excerpt

OBJECTIVE: For patients with locally advanced rectal cancer (LARC), adjuvant chemotherapy selection following surgery remains a major clinical dilemma. Here, we investigated the ability of circulating tumour DNA (ctDNA) to improve risk stratification in patients with LARC. DESIGN: We enrolled patients with LARC (T3/T4 and/or N+) planned for neoadjuvant chemoradiotherapy. Plasma samples were collected...

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Identifiers

PMID: 29420226
DOI: 10.1136/gutjnl-2017-315852
PMCID: PMC6265124

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