Article
Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies.
Science translational medicine - 18 Jan 2017
Petrovas Constantinos, Ferrando-Martinez Sara, Gerner Michael Y, Casazza Joseph P, Pegu Amarendra, Deleage Claire, Cooper Arik, Hataye Jason, Andrews Sarah, Ambrozak David, Del Río Estrada Perla M, Boritz Eli, Paris Robert, Moysi Eirini, Boswell Kristin L, Ruiz-Mateos Ezequiel, Vagios Ilias, Leal Manuel, Ablanedo-Terrazas Yuria, Rivero Amaranta, Gonzalez-Hernandez Luz Alicia, McDermott Adrian B, Moir Susan, Reyes-Terán Gustavo, Docobo Fernando, Pantaleo Giuseppe, Douek Daniel C, Betts Michael R, Estes Jacob D, Germain Ronald N, Mascola John R, Koup Richard A
Abstract excerpt
Cytolytic CD8 T cells play a crucial role in the control and elimination of virus-infected cells and are a major focus of HIV cure efforts. However, it has been shown that HIV-specific CD8 T cells are infrequently found within germinal centers (GCs), a predominant site of active and latent HIV infection. We demonstrate that HIV infection induces marked changes in the phenotype, frequency, and localization of CD8...
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