Article
[Role of Follicular helper CD4 T cells in HIV/SIV infection].
Uirusu - 1 Jan 2012
Yamamoto Takuya
Abstract excerpt
Follicular CD4 T helper (TFH) cells promote the survival, isotype switching and generation of high affinity memory B cells and plasma cells. There are numerous reports regarding the dysfunction of B cell mediated immune responses, the lack of memory CD4 T cells and the dysfunction of HIV specific CD4 T cells in SIV/HIV infection. During chronic SIV/HIV infection, TFH cell accumulation may drive B cell dysfunction...
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