Article
Phenotypic and functional characterization of HIV-1-specific CD4+CD8+ double-positive T cells in early and chronic HIV-1 infection.
Journal of acquired immune deficiency syndromes (1999) - 15 Apr 2009
Howe Rawleigh, Dillon Stephanie, Rogers Lisa, Palmer Brent, MaWhinney Samantha, Blyveis Naomi, Schlichtemeier Rick, D'Souza Michelle, Ingoldby Laura, Harwood Jeri E F, Rietmeijer Cornelis, Ray Graham, Connick Elizabeth, Wilson Cara C
Abstract excerpt
OBJECTIVE: CD4+CD8+ double-positive (DP) T cells represent a poorly characterized population of effector T cells found at low frequencies in the peripheral blood. Virus-specific DP T cells have been identified in HIV-1-infected patients but their origin, relationship to conventional CD4+ and CD8+ single-positive (SP) T cells, and role in disease pathogenesis are unclear. METHODS: In this study, peripheral blood T...
Topics
- Adult
- CD4 Lymphocyte Count
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Chronic Disease
- Cytokines
- Female
- HIV Infections
- HIV-1
- Humans
- Immunologic Memory
- Male