Article
Kruppel-like factor4 regulates PRDM1 expression through binding to an autoimmune risk allele.
JCI insight - 12 Jan 2017
Jang Su Hwa, Chen Helen, Gregersen Peter K, Diamond Betty, Kim Sun Jung
Abstract excerpt
A SNP identified as rs548234, which is found in PRDM1, the gene that encodes BLIMP1, is a risk allele associated with systemic lupus erythematosus (SLE). BLIMP1 expression was reported to be decreased in women with the PRDM1 rs548234 risk allele compared with women with the nonrisk allele in monocyte-derived DCs (MO-DCs). In this study, we demonstrate that BLIMP1 expression is regulated by the binding of...
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