Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inducible deletion of the Blimp-1 gene in adult epidermis causes granulocyte-dominated chronic skin inflammation in mice

1 Apr 2013

Abstract excerpt

B lymphocyte-induced maturation protein-1 (Blimp-1) is a transcriptional repressor important for the differentiation and function of several types of immune cells. Because skin serves as a physical barrier and acts as an immune sentinel, we investigated whether Blimp-1 is involved in epidermal immune function. We show that Blimp-1 expression is reduced in skin lesions of some human eczema samples and in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to IL-33, ST2, and ILC Pathways
Share to Inflammasome and immune disorders
Share to Whipple's Disease and Interleukins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23576729
DOI: 10.1073/pnas.1219462110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inducible deletion of the Blimp-1 gene in adult epidermis causes granulocyte-dominated chronic skin inflammation in micePMID 23576729Read ↗

Immunological function of Blimp-1 in dendritic cells and relevance to autoimmune diseases.Semantic proximity Read ↗

Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1.Semantic proximity Read ↗

Signalling in inflammatory skin disease by AP-1 (Fos/Jun).Semantic proximity Read ↗

Blimp-1 Contributes to the Development and Function of Regulatory B CellsSemantic proximity Read ↗

Blimp-1 and c-Maf regulate common and unique gene networks to protect against distinct pathways of pathobiont-induced colitisSemantic proximity Read ↗

PRDM1/BLIMP1: a tumor suppressor gene in B and T cell lymphomasSemantic proximity Read ↗

The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice.Semantic proximity Read ↗

Transcription Factor Blimp-1: A Central Regulator of Oxidative Stress and Metabolic Reprogramming in Chronic Inflammatory DiseasesSemantic proximity Read ↗

Blimp-1 is essential for allergen-induced asthma and Th2 cell development in the lungSemantic proximity Read ↗

Genetic control directed toward spontaneous IFN-alpha/IFN-beta responses and downstream IFN-gamma expression influences the pathogenesis of a murine psoriasis-like skin disease.Semantic proximity Read ↗

A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasiaSemantic proximity Read ↗

Pellino1 promotes chronic inflammatory skin disease via keratinocyte hyperproliferation and induction of the T helper 17 response.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.