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Article

PRDM1/BLIMP1: a tumor suppressor gene in B and T cell lymphomas

13 Aug 2014

Abstract excerpt

The gene encoding the human BLIMP1, prdm1, is located on chromosome 6q21, a locus frequently deleted in lymphoid tumors. BLIMP1 is able to silence its target genes in a context-dependent manner through different mechanisms. BLIMP1 is expressed in both B and T cells, in which it plays important functions. In B cells, BLIMP1 acts as the master regulator of plasma cell differentiation, repressed by BCL6 and...

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Identifiers

PMID: 25115512
DOI: 10.3109/10428194.2014.953155

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