Genomic Multiple Sclerosis Risk Variants Modulate the Expression of the ANKRD55-IL6ST Gene Region in Immature Dendritic Cells.

doi:10.3389/fimmu.2021.816930

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Article

Genomic Multiple Sclerosis Risk Variants Modulate the Expression of the ANKRD55-IL6ST Gene Region in Immature Dendritic Cells.

Frontiers in immunology - 1 Jan 2021

Mena Jorge, Alloza Iraide, Tulloch Navarro Raquel, Aldekoa Ane, Díez García Javier, Villanueva Etxebarria Ane, Lindskog Cecilia, Antigüedad Alfredo, Boyero Sabas, Mendibe-Bilbao María Del Mar, Álvarez de Arcaya Amaya, Sánchez Menoyo José Luis, Midaglia Luciana, Villarrubia Noelia, Malhotra Sunny, Montalban Xavier, Villar Luisa María, Comabella Manuel, Vandenbroeck Koen

Abstract excerpt

Intronic single-nucleotide polymorphisms (SNPs) in the ANKRD55 gene are associated with the risk for multiple sclerosis (MS) and rheumatoid arthritis by genome-wide association studies (GWAS). The risk alleles have been linked to higher expression levels of ANKRD55 and the neighboring IL6ST (gp130) gene in CD4+ T lymphocytes of healthy controls. The biological function of ANKRD55, its role in the immune system,...

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Identifiers

PMID: 35111166
DOI: 10.3389/fimmu.2021.816930
PMCID: PMC8801523

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