Article

Exosome-shuttled miRNAs contribute to the modulation of the neuroinflammatory microglia phenotype by mesenchymal stem cells. Implication for amyotrophic lateral sclerosis

2019-11-28

Abstract excerpt

<title>Abstract</title> <p>Background Mesenchymal stromal/stem cells (MSCs) are characterized by neuroprotective, immunomodulatory, and neuroregenerative properties, which support their therapeutic potential for neurodegenerative diseases driven by microglia-associated inflammation, such as amyotrophic lateral sclerosis (ALS). One mode of action through which MSCs exert their immunomodulatory effects is the relea...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aa0e823e-2431-5e8f-9d6f-9666d36b011a
DOI: 10.21203/rs.2.17858/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exosome-shuttled miRNAs contribute to the modulation of the neuroinflammatory microglia phenotype by mesenchymal stem cells. Implication for amyotrophic lateral sclerosisDOI 10.21203/rs.2.17858/v1Read

Potential of activated microglia as a source of dysregulated extracellular microRNAs contributing to neurodegeneration in amyotrophic lateral sclerosisSemantic proximity Read

Mesenchymal stem cell-derived exosomes inhibit Aβ1-42 induced microglia polarization by TLR2/MYD88/NF-κB pathwaySemantic proximity Read

Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization.Semantic proximity Read

Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammationSemantic proximity Read

Distinct repertoires of microRNAs present in mouse astrocytes compared to astrocyte-secreted exosomesSemantic proximity Read

Exosome Release Promotes Inflammatory Resolution in Activated and Aged MicrogliaSemantic proximity Read

An ALS-associated mutation dysregulates microglia-derived extracellular microRNAs in a sex-specific manner.Semantic proximity Read

Wnt5a-Induced Exosomes From Bone Marrow Mesenchymal Stem Cells Promote Spinal Cord Injury Repair by Modulating Immune Cell Phenotypes and Alleviating Neuroinflammation via the NF-κB Pathway.Semantic proximity Read

BM-MSCs ameliorate experimental autoimmune encephalomyelitis via modifying the expression of miR-193, miR-146a, miR-155, miR-21 and miR-326Semantic proximity Read

ALS iPSC-derived microglia and motor neurons respond to astrocyte-targeted IL-10 and CCL2 modulationSemantic proximity Read

Astrocyte-derived exosomes enriched with miR-873a-5p inhibit neuroinflammation via microglia phenotype modulation after traumatic brain injurySemantic proximity Read

HuR promotes the molecular signature and phenotype of activated microglia: Implications for amyotrophic lateral sclerosis and other neurodegenerative diseasesSemantic proximity Read