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Article

Aberrant activation of p53 due to loss of MDM2 or MDMX causes early lens dysmorphogenesis.

Developmental biology - 1 Dec 2014

Zhang Yiwei, Zhang Xin, Lu Hua

Abstract excerpt

Although forming a heterodimer or heterooligomer is essential for MDM2 and MDMX to fully control p53 during early embryogenesis, deletion of either MDM2 or MDMX in specific tissues using the loxp-Cre system reveals phenotypic diversity during organ morphogenesis, which can be completely rescued b...

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Share to Apoptosis
Share to Gene Expression Regulation, Developmental
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lens, Crystalline

Share to Morphogenesis

Share to Proto-Oncogene Proteins c-mdm2

Share to Retinoblastoma Protein

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 25263199
DOI: 10.1016/j.ydbio.2014.09.017
PMCID: PMC5393629

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25263199-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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