Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease.

Human molecular genetics - 1 Feb 2017

Sandor Cynthia, Robertson Paul, Lang Charmaine, Heger Andreas, Booth Heather, Vowles Jane, Witty Lorna, Bowden Rory, Hu Michele, Cowley Sally A, Wade-Martins Richard, Webber Caleb

Abstract excerpt

While induced pluripotent stem cell (iPSC) technologies enable the study of inaccessible patient cell types, cellular heterogeneity can confound the comparison of gene expression profiles between iPSC-derived cell lines. Here, we purified iPSC-derived human dopaminergic neurons (DaNs) using the intracellular marker, tyrosine hydroxylase. Once purified, the transcriptomic profiles of iPSC-derived DaNs appear...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autopsy
Share to Dopamine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopaminergic Neurons

Share to Induced Pluripotent Stem Cells

Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Share to Parkinson Disease

Share to Rotenone

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 28096185
DOI: 10.1093/hmg/ddw412
PMCID: PMC5409122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease.PMID 28096185Read ↗

Convergent transcriptomic signature in iPSC-dopaminergic neurons of hereditary Parkinson's disease.Semantic proximity Read ↗

Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiationSemantic proximity Read ↗

Single-cell transcriptomics of human iPSC differentiation dynamics reveal a core molecular network of Parkinson's disease.Semantic proximity Read ↗

Druggable transcriptomic pathways revealed in Parkinson’s patient-derived midbrain neuronsSemantic proximity Read ↗

Brain transcriptomic profiling in idiopathic and LRRK2-associated Parkinson's diseaseSemantic proximity Read ↗

Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson's Disease Patients.Semantic proximity Read ↗

Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation.Semantic proximity Read ↗

Phenotypic Profiling of Human Stem Cell-Derived Midbrain Dopaminergic Neurons.Semantic proximity Read ↗

Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity.Semantic proximity Read ↗

Understanding disease and disease relationships using transcriptomic dataSemantic proximity Read ↗

Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cellsSemantic proximity Read ↗

Pluripotent stem cell derived models of neurological diseases reveal early transcriptional heterogeneitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.