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Article

Convergent transcriptomic signature in iPSC-dopaminergic neurons of hereditary Parkinson's disease.

Life science alliance - 1 Jul 2026

Kopylova Irina V, Ivanov Artem B, Eidelman Lev R, Zaitseva Ekaterina N, Kulikova Ekaterina D, Grehnyov Dmitriy A, Bogomazova Alexandra N, Vigont Vladimir A, Kaznacheyeva Elena V, Lagarkova Maria A, Lebedeva Olga S, Olekhnovich Evgenii I

Abstract excerpt

The clinical and genetic diversity of Parkinson's disease (PD) makes it challenging to identify common mechanisms across different forms. To search for such shared pathways, we performed transcriptomic analysis of iPSC-derived dopaminergic neurons from patients with LRRK2 or Parkin mutations. We discovered a convergent gene expression signature in both genetic backgrounds, indicating a shift away from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42031673
DOI: 10.26508/lsa.202503551
PMCID: PMC13109591

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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