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Genetic programming of macrophages generates an in vitro model for the human erythroid island niche

20 Feb 2019

Abstract excerpt

Abstract Red blood cells mature within the erythroblastic island (EI) niche that consists of specialized macrophages surrounded by differentiating erythroblasts. Here we establish an in vitro system to model the human EI niche using macrophages that are derived from human induced pluripotent stem cells (iPSCs), and are also genetically programmed to an EI-like phenotype by inducible activation of the...

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PMID: 30787325
DOI: 10.1038/s41467-019-08705-0

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