Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function

24 Aug 2018

Abstract excerpt

hematopoietic stem and progenitor cells (HSPC) has low surface expression of pDC markers, and has limited induction of type I interferon (IFN) and IL-6 upon TLR7 and TLR9 agonists treatment; by contrast, cGAS or RIG-I agonists-mediated activation is not altered. Importantly, after priming with type I and II IFN, these precursor pDCs attain a phenotype and functional activity similar to that of peripheral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immunotherapy and Immune Responses
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30166549
DOI: 10.1038/s41467-018-05816-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and functionPMID 30166549Read ↗

A gene silencing pipeline to interrogate human cDC1 and pDC development and functionsSemantic proximity Read ↗

Modelling IRF8 Deficient Human Hematopoiesis and Dendritic Cell Development with Engineered iPS CellsSemantic proximity Read ↗

Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and HeterogeneitySemantic proximity Read ↗

Phenotypical Diversification of Early IFNα-Producing Human Plasmacytoid Dendritic Cells Using Droplet-Based Microfluidics.Semantic proximity Read ↗

Lineage specification of human dendritic cells is marked by IRF8 expression in hematopoietic stem cells and multipotent progenitorsSemantic proximity Read ↗

The Role of Interferon-Gamma in Hematopoietic Stem Cell Development, Homeostasis, and DiseaseSemantic proximity Read ↗

Interferon-producing cells develop from murine CD31(high)/Ly6C(-) marrow progenitors.Semantic proximity Read ↗

Plasmacytoid dendritic cells: key players in the initiation and regulation of immune responses.Semantic proximity Read ↗

PD-L1 regulates inflammatory macrophage development from human pluripotent stem cells by maintaining interferon-gamma signalSemantic proximity Read ↗

Unilineage monocytopoiesis in hematopoietic progenitor culture: switching cytokine treatment at all Mo developmental stages induces differentiation into dendritic cells.Semantic proximity Read ↗

Guidelines for mouse and human DC generation.Semantic proximity Read ↗

Understanding and Modulating Immunity With Cell ReprogrammingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.