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Article

The lack of either IRF9, or STAT2, has surprisingly little effect on human natural killer cell development and function.

Immunology - 1 Jul 2024

Calvo-Apalategi Ane, Nevado Marta López, Bravo-Gallego Luz Yadira, González-Granado Luis Ignacio, Allende Luis M, Pena Rebeca Rodríguez, López-Granados Eduardo, Reyburn Hugh T

Abstract excerpt

Analysis of genetically defined immunodeficient patients allows study of the effect of the absence of specific proteins on human immune function in real-world conditions. Here we have addressed the importance of type I interferon signalling for human NK cell development by studying the phenotype and function of circulating NK cells isolated from patients suffering primary immunodeficiency disease due to mutation...

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Share to Cell Differentiation
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon Type I

Share to Killer Cells, Natural

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Share to Signal Transduction

Share to STAT1 Transcription Factor

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Identifiers

PMID: 38514903
DOI: 10.1111/imm.13779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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