Article
The multitargeted receptor tyrosine kinase inhibitor linifanib (ABT-869) induces apoptosis through an Akt and glycogen synthase kinase 3β-dependent pathway.
Molecular cancer therapeutics - 1 Jun 2011
Hernandez-Davies Jenny E, Zape Joan P, Landaw Elliot M, Tan Xiaolin, Presnell Ajia, Griffith Diana, Heinrich Michael C, Glaser Keith B, Sakamoto Kathleen M
Abstract excerpt
The FMS-like receptor tyrosine kinase 3 (FLT3) plays an important role in controlling differentiation and proliferation of hematopoietic cells. Activating mutations in FLT3 occur in patients with acute myeloid leukemia (AML; 15%-35%), resulting in abnormal cell proliferation. Furthermore, both adult and pediatric patients with AML harboring the FLT3 internal tandem duplication (ITD) mutation have a poor...
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