Article
Mouse Genome-Wide Association Study of Preclinical Group II Pulmonary Hypertension Identifies Epidermal Growth Factor Receptor.
American journal of respiratory cell and molecular biology - 1 Apr 2017
Kelly Neil J, Radder Josiah E, Baust Jeffrey J, Burton Christine L, Lai Yen-Chun, Potoka Karin C, Agostini Brittani A, Wood John P, Bachman Timothy N, Vanderpool Rebecca R, Dandachi Nadine, Leme Adriana S, Gregory Alyssa D, Morris Alison, Mora Ana L, Gladwin Mark T, Shapiro Steven D
Abstract excerpt
Pulmonary hypertension (PH) is associated with features of obesity and metabolic syndrome that translate to the induction of PH by chronic high-fat diet (HFD) in some inbred mouse strains. We conducted a genome-wide association study (GWAS) to identify candidate genes associated with susceptibility to HFD-induced PH. Mice from 36 inbred and wild-derived strains were fed with regular diet or HFD for 20 weeks...
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