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Article

Evaluating diabetes and hypertension disease causality using mouse phenotypes.

BMC systems biology - 20 Jul 2010

Yu Hong, Huang Jialiang, Qiao Nan, Green Christopher D, Han Jing-Dong J

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have found hundreds of single nucleotide polymorphisms (SNPs) associated with common diseases. However, it is largely unknown what genes linked with the SNPs actually implicate disease causality. A definitive proof for disease causality can be demonstration of disease-like phenotypes through genetic perturbation of the genes or alleles, which is obviously a...

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Identifiers

PMID: 20642857
DOI: 10.1186/1752-0509-4-97
PMCID: PMC2917432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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