Article
Drug screening with zebrafish visual behavior identifies carvedilol as a potential treatment for an autosomal dominant form of retinitis pigmentosa.
Scientific reports - 1 Jun 2021
Ganzen Logan, Ko Mee Jung, Zhang Mengrui, Xie Rui, Chen Yongkai, Zhang Liyun, James Rebecca, Mumm Jeff, van Rijn Richard M, Zhong Wenxuan, Pang Chi Pui, Zhang Mingzhi, Tsujikawa Motokazu, Leung Yuk Fai
Abstract excerpt
Retinitis Pigmentosa (RP) is a mostly incurable inherited retinal degeneration affecting approximately 1 in 4000 individuals globally. The goal of this work was to identify drugs that can help patients suffering from the disease. To accomplish this, we screened drugs on a zebrafish autosomal dominant RP model. This model expresses a truncated human rhodopsin transgene (Q344X) causing significant rod degeneration...
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