Article

Zebrafish Functional Screening of FDA-Approved Drugs for Autosomal Dominant Retinitis Pigmentosa Caused by RHODOPSIN Q344X Mutation

2026-04-21

Abstract excerpt

<h4>ABSTRACT</h4> Retinitis Pigmentosa (RP) is a group of inherited retinal degenerations for which most subtypes lack effective drug treatments. This challenge is particularly critical for autosomal dominant (ad) RP, which is often unsuitable for gene replacement therapy. To address this challenge, we screened an FDA-approved compound library using a zebrafish adRP model expressing a human RHODOPSIN transgene wi...

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Literature Corpus work: dcf9ec61-fd8f-5000-bd5f-5d10c980ee6a
DOI: 10.64898/2026.04.18.719270

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