Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa.

doi:10.7554/eLife.57245

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Article

Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa.

eLife - 29 Jun 2021

Zhang Liyun, Chen Conan, Fu Jie, Lilley Brendan, Berlinicke Cynthia, Hansen Baranda, Ding Ding, Wang Guohua, Wang Tao, Shou Daniel, Ye Ying, Mulligan Timothy, Emmerich Kevin, Saxena Meera T, Hall Kelsi R, Sharrock Abigail V, Brandon Carlene, Park Hyejin, Kam Tae-In, Dawson Valina L, Dawson Ted M, Shim Joong Sup, Hanes Justin, Ji Hongkai, Liu Jun O, Qian Jiang, Ackerley David F, Rohrer Baerbel, Zack Donald J, Mumm Jeff S

Abstract excerpt

Retinitis pigmentosa (RP) and associated inherited retinal diseases (IRDs) are caused by rod photoreceptor degeneration, necessitating therapeutics promoting rod photoreceptor survival. To address this, we tested compounds for neuroprotective effects in multiple zebrafish and mouse RP models, reasoning drugs effective across species and/or independent of disease mutation may translate better clinically. We first...

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PMID: 34184634
DOI: 10.7554/eLife.57245
PMCID: PMC8425951

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