Article
The crystal structure of the 5΄ functional domain of the transcription riboregulator 7SK.
Nucleic acids research - 7 Apr 2017
Martinez-Zapien Denise, Legrand Pierre, McEwen Alastair G, Proux Florence, Cragnolini Tristan, Pasquali Samuela, Dock-Bregeon Anne-Catherine
Abstract excerpt
In vertebrates, the 7SK RNA forms the scaffold of a complex, which regulates transcription pausing of RNA-polymerase II. By binding to the HEXIM protein, the complex comprising proteins LARP7 and MePCE captures the positive transcription elongation factor P-TEFb and prevents phosphorylation of pausing factors. The HEXIM-binding site embedded in the 5΄-hairpin of 7SK (HP1) encompasses a short signature sequence, a...
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