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Article

Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM.

Nucleic acids research - 1 Dec 2016

Varshney Dhaval, Petit Alain-Pierre, Bueren-Calabuig Juan A, Jansen Chimed, Fletcher Dan A, Peggie Mark, Weidlich Simone, Scullion Paul, Pisliakov Andrei V, Cowling Victoria H

Abstract excerpt

Maturation and translation of mRNA in eukaryotes requires the addition of the 7-methylguanosine cap. In vertebrates, the cap methyltransferase, RNA guanine-7 methyltransferase (RNMT), has an activating subunit, RNMT-Activating Miniprotein (RAM). Here we report the first crystal structure of the human RNMT in complex with the activation domain of RAM. A relatively unstructured and negatively charged RAM binds to a...

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Source

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Identifiers

PMID: 27422871
DOI: 10.1093/nar/gkw637
PMCID: PMC5137418

Genes

RNMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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