Article
Mutational analysis and clinical correlation of metastatic colorectal cancer.
Cancer - 15 May 2014
Russo Andrea L, Borger Darrell R, Szymonifka Jackie, Ryan David P, Wo Jennifer Y, Blaszkowsky Lawrence S, Kwak Eunice L, Allen Jill N, Wadlow Raymond C, Zhu Andrew X, Murphy Janet E, Faris Jason E, Dias-Santagata Dora, Haigis Kevin M, Ellisen Leif W, Iafrate Anthony J, Hong Theodore S
Abstract excerpt
BACKGROUND: Early identification of mutations may guide patients with metastatic colorectal cancer toward targeted therapies that may be life prolonging. The authors assessed tumor genotype correlations with clinical characteristics to determine whether mutational profiling can account for clinic...
Topics
- Adenocarcinoma
- Adenomatous Polyposis Coli Protein
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
- Class I Phosphatidylinositol 3-Kinases
- Colonic Neoplasms
- DNA Mutational Analysis
- Female
- GTP Phosphohydrolases
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic