Comprehensive association analysis of 27 genes from the GABAergic system in Japanese individuals affected with schizophrenia.

doi:10.1016/j.schres.2017.01.003

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Article

Comprehensive association analysis of 27 genes from the GABAergic system in Japanese individuals affected with schizophrenia.

Schizophrenia research - 1 Jul 2017

Balan Shabeesh, Yamada Kazuo, Iwayama Yoshimi, Hashimoto Takanori, Toyota Tomoko, Shimamoto Chie, Maekawa Motoko, Takagai Shu, Wakuda Tomoyasu, Kameno Yosuke, Kurita Daisuke, Yamada Kohei, Kikuchi Mitsuru, Hashimoto Tasuku, Kanahara Nobuhisa, Yoshikawa Takeo

Abstract excerpt

Involvement of the gamma-aminobutyric acid (GABA)-ergic system in schizophrenia pathogenesis through disrupted neurodevelopment has been highlighted in numerous studies. However, the function of common genetic variants of this system in determining schizophrenia risk is unknown. We therefore tested the association of 375 tagged SNPs in genes derived from the GABAergic system, such as GABAA receptor subunit genes,...

Topics

Adult
Aged
Asian People
Carrier Proteins
Female
Gene Frequency
Genetic Predisposition to Disease
Genetic Testing
Glutamate Decarboxylase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Linkage Disequilibrium

Male

Membrane Proteins

Middle Aged

Polymorphism, Single Nucleotide

Receptors, GABA

Schizophrenia

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 28073605
DOI: 10.1016/j.schres.2017.01.003

Genes

GPHN
GABRA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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