Article
Meta-analysis of GABRB2 polymorphisms and the risk of schizophrenia combined with GWAS data of the Han Chinese population and psychiatric genomics consortium.
PloS one - 1 Jan 2018
Zhang Tian, Li Jun, Yu Hao, Shi Yongyong, Li Zhiqiang, Wang Linyan, Wang Ziqi, Lu Tianlan, Wang Lifang, Yue Weihua, Zhang Dai
Abstract excerpt
Schizophrenia (SCZ) is a severe psychiatric disorder with evidence of a strong genetic component in the complex etiologies. Some studies indicated that gamma-aminobutyric acid (GABA)A receptor β2 subunit gene (GABRB2) was associated with SCZ. Other studies reported a negative association. Moreover, the results of two previous meta-analyses of GABRB2 with SCZ were inconsistent and the sample sizes were limited....
Topics
- Case-Control Studies
- China
- Databases, Factual
- Genetic Predisposition to Disease
- Humans
- Polymorphism, Single Nucleotide
- Prognosis
- Receptors, GABA-A
- Schizophrenia