Article
Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia.
Molecular psychiatry - 1 Dec 2005
Petryshen T L, Middleton F A, Tahl A R, Rockwell G N, Purcell S, Aldinger K A, Kirby A, Morley C P, McGann L, Gentile K L, Waggoner S G, Medeiros H M, Carvalho C, Macedo A, Albus M, Maier W, Trixler M, Eichhammer P, Schwab S G, Wildenauer D B, Azevedo M H, Pato M T, Pato C N, Daly M J, Sklar P
Abstract excerpt
We previously performed a genome-wide linkage scan in Portuguese schizophrenia families that identified a risk locus on chromosome 5q31-q35. This finding was supported by meta-analysis of 20 other schizophrenia genome-wide scans that identified 5q23.2-q34 as the second most compelling susceptibility locus in the genome. In the present report, we took a two-stage candidate gene association approach to investigate...
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