Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytochrome P450 Allele CYP3A7*1C Associates with Adverse Outcomes in Chronic Lymphocytic Leukemia, Breast, and Lung Cancer.

Cancer research - 15 Mar 2016

Johnson Nichola, De Ieso Paolo, Migliorini Gabriele, Orr Nick, Broderick Peter, Catovsky Daniel, Matakidou Athena, Eisen Timothy, Goldsmith Christy, Dudbridge Frank, Peto Julian, Dos-Santos-Silva Isabel, Ashworth Alan, Ross Gillian, Houlston Richard S, Fletcher Olivia

Abstract excerpt

CYP3A enzymes metabolize endogenous hormones and chemotherapeutic agents used to treat cancer, thereby potentially affecting drug effectiveness. Here, we refined the genetic basis underlying the functional effects of a CYP3A haplotype on urinary estrone glucuronide (E1G) levels and tested for an association between CYP3A genotype and outcome in patients with chronic lymphocytic leukemia (CLL), breast, or lung...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Aryl Hydrocarbon Hydroxylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Breast Neoplasms

Share to Cytochrome P-450 CYP3A

Share to Estrone

Share to Glucuronides

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Lung Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 26964624
DOI: 10.1158/0008-5472.CAN-15-1410
PMCID: PMC4795533

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytochrome P450 Allele CYP3A7*1C Associates with Adverse Outcomes in Chronic Lymphocytic Leukemia, Breast, and Lung Cancer.PMID 26964624Read ↗

CYP3A7*1C allele is associated with reduced levels of 2-hydroxylation pathway oestrogen metabolites.Semantic proximity Read ↗

CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers.Semantic proximity Read ↗

CYP3A variation, premenopausal estrone levels, and breast cancer risk.Semantic proximity Read ↗

Role of cytochrome P450 genes in breast cancer etiology and treatment: effects on estrogen biosynthesis, metabolism, and response to endocrine therapy.Semantic proximity Read ↗

Pharmacogenetics of estrogen metabolism and transport in relation to cancer.Semantic proximity Read ↗

CYP17 gene polymorphisms: prevalence and associations with hormone levels and related factors. a HuGE review.Semantic proximity Read ↗

CYP17 genetic variation and risk of breast and prostate cancer from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3).Semantic proximity Read ↗

Drug metabolising enzyme polymorphisms and chemotherapy-related ovarian failure in young breast cancer survivors.Semantic proximity Read ↗

SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+ breast cancer: genome-wide association studies of the estrone pathway.Semantic proximity Read ↗

The role of polymorphic cytochrome P450 gene (CYP2B6) in B-chronic lymphocytic leukemia (B-CLL) incidence and outcome among Egyptian patients.Semantic proximity Read ↗

A pharmacogenomics study of the human estrogen glucuronosyltransferase UGT1A3.Semantic proximity Read ↗

Risk of testicular germ cell cancer in relation to variation in maternal and offspring cytochrome p450 genes involved in catechol estrogen metabolism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.