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Article

Association of CYP3A7*1C and serum dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome.

The Journal of clinical endocrinology and metabolism - 1 Jul 2008

Goodarzi Mark O, Xu Ning, Azziz Ricardo

Abstract excerpt

CONTEXT: Adrenal androgen excess is common in polycystic ovary syndrome (PCOS) and appears to be heritable. CYP3A7 metabolizes dehydroepiandrosterone and its sulfate (DHEAS). A promoter variant, CYP3A7*1C, which results in persistent expression in adults, was associated with reduced DHEAS levels in a previous study, which led us to consider CYP3A7*1C as a modulator of adrenal androgen excess in patients with...

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Share to Aryl Hydrocarbon Hydroxylases
Share to Cytochrome P-450 CYP3A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18445661
DOI: 10.1210/jc.2008-0403
PMCID: PMC2453058

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Association of CYP3A7*1C and serum dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome.PMID 18445661Read ↗

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