Article
A common polymorphism in the CYP3A7 gene is associated with a nearly 50% reduction in serum dehydroepiandrosterone sulfate levels.
The Journal of clinical endocrinology and metabolism - 1 Sept 2005
Smit Pauline, van Schaik Ron H N, van der Werf Marloes, van den Beld Annewieke W, Koper Jan W, Lindemans Jan, Pols Huibert A P, Brinkmann Albert O, de Jong Frank H, Lamberts Steven W J
Abstract excerpt
CONTEXT: CYP3A7, expressed in the human fetal liver and normally silenced after birth, plays a major role in the 16alpha-hydroxylation of dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), and estrone. Due to a replacement of part of the CYP3A7 promoter with a sequence identical with the same region in the CYP3A4 promoter (referred to as CYP3A7*1C), some individuals still express a variant of the CYP3A7 gene...
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