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Estrogen-metabolizing gene polymorphisms and age at natural menopause in Caucasian women.

Human reproduction (Oxford, England) - 1 May 2005

Hefler L A, Grimm C, Heinze G, Schneeberger C, Mueller M W, Muendlein A, Huber J C, Leodolter S, Tempfer C B

Abstract excerpt

BACKGROUND: Lifestyle parameters, personal history and genetic factors are thought to affect the timing of natural menopause in humans. Based on their biological function, estrogen-metabolizing gene polymorphisms have been regarded as candidate genes for early menopause. METHODS: In the present cross-sectional, multi-centre study, we analysed nine single nucleotide polymorphisms of six estrogen-metabolizing genes...

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PMID: 15774541
DOI: 10.1093/humrep/deh848

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