Article
Genome-wide significant risk loci for mood disorders in the Old Order Amish founder population.
Molecular psychiatry - 1 Dec 2023
Humphries Elizabeth M, Ahn Kwangmi, Kember Rachel L, Lopes Fabiana L, Mocci Evelina, Peralta Juan M, Blangero John, Glahn David C, Goes Fernando S, Zandi Peter P, Kochunov Peter, Van Hout Cristopher, Shuldiner Alan R, Pollin Toni I, Mitchell Braxton D, Bucan Maja, Hong L Elliot, McMahon Francis J, Ament Seth A
Abstract excerpt
Genome-wide association studies (GWAS) of mood disorders in large case-control cohorts have identified numerous risk loci, yet pathophysiological mechanisms remain elusive, primarily due to the very small effects of common variants. We sought to discover risk variants with larger effects by conducting a genome-wide association study of mood disorders in a founder population, the Old Order Amish (OOA, n = 1,672)....
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