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Article

Ribosomal protein pNO40 mediates nucleolar sequestration of SR family splicing factors and its overexpression impairs mRNA metabolism.

Cellular signalling - 1 Apr 2017

Lin Yen-Ming, Chu Pao-Hsien, Li Yun-Zhu, Ouyang Pin

Abstract excerpt

The nucleolus acts as a key stress sensor and responds to changes in cellular growth rate and metabolic activity. In addition to its major role as the site of ribosome biogenesis, high-throughput proteomic analyses of purified nucleoli have highlighted the multi-functional nature of these organelles, and several SR family splicing factors, including SRSF1 and SRSF2, have been detected in human nucleolar proteome...

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Source

Identifiers

PMID: 28069438
DOI: 10.1016/j.cellsig.2017.01.010

Genes

SRSF1
SRSF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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