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Article

Horizontally acquired AT-rich genes in Escherichia coli cause toxicity by sequestering RNA polymerase.

Nature microbiology - 9 Jan 2017

Lamberte Lisa E, Baniulyte Gabriele, Singh Shivani S, Stringer Anne M, Bonocora Richard P, Stracy Mathew, Kapanidis Achillefs N, Wade Joseph T, Grainger David C

Abstract excerpt

Horizontal gene transfer permits rapid dissemination of genetic elements between individuals in bacterial populations. Transmitted DNA sequences may encode favourable traits. However, if the acquired DNA has an atypical base composition, it can reduce host fitness. Consequently, bacteria have evolved strategies to minimize the harmful effects of foreign genes. Most notably, xenogeneic silencing proteins bind...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28067866
DOI: 10.1038/nmicrobiol.2016.249
PMCID: PMC7610989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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