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Article

Mapping the Phospho-dependent ALK Interactome to Identify Novel Components in ALK Signaling

1 Oct 2021

Abstract excerpt

Protein-protein interactions (PPIs) play essential roles in Anaplastic Lymphoma Kinase (ALK) signaling. Systematic characterization of ALK interactors helps elucidate novel ALK signaling mechanisms and may aid in the identification of novel therapeutics targeting related diseases. In this study, we used the Mammalian Membrane Two-Hybrid (MaMTH) system to map the phospho-dependent ALK interactome. By screening a...

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PMID: 34606829
DOI: 10.1016/j.jmb.2021.167283

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