Article
Differentiation factors and cytokines in the atherosclerotic plaque micro-environment as a trigger for macrophage polarisation.
Thrombosis and haemostasis - 1 Nov 2011
Wolfs I M J, Donners M M P C, de Winther M P J
Abstract excerpt
The phenotype of macrophages in atherosclerotic lesions can vary dramatically, from a large lipid laden foam cell to a small inflammatory cell. Classically, the concept of macrophage heterogeneity discriminates between two extremes called either pro-inflammatory M1 macrophages or anti-inflammatory M2 macrophages. Polarisation of plaque macrophages is predominantly determined by the local micro-environment present...
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