Article
Nek6 knockdown polarized macrophages into a pro-inflammatory phenotype via inhibiting STAT3 expression.
International journal of experimental pathology - 1 Oct 2023
Wu Xiaoyan, Deng Ke-Qiong, Cai Huan-Huan, Zeng Ziyue, Cao Jian-Lei, Zhang Lin, Lu Zhibing, Cheng Wen-Lin
Abstract excerpt
Recently macrophage polarization has emerged as playing an essential role in the oathogenesis of atherosclerosis, which is the most important underlying process in many types of cardiovascular diseases. Although Nek6 has been reported to be involved in various cellular processes, the effect of Nek6 on macrophage polarization remains unknown. Macrophages exposed to lipopolysaccharide (LPS) or IL-4 were used to...
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