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Article

Unique molecular signatures in rebound viruses from antiretroviral drug and CRISPR-treated HIV-1-infected humanized mice.

Communications biology - 19 Jul 2025

Zhang Chen, Li Haotian, Poluektova Larisa Y, Gendelman Howard E, Dash Prasanta K

Abstract excerpt

HIV-1 elimination from a subset of virus-infected humanized mice (hu-mice) is reported following sequential dual treatment with long-acting (LA) antiretroviral (ART) and CRISPR-Cas9 therapies. However, viral rebound is observed in > 50% of the dual-treated animals. The molecular signatures of the rebound virus, recovered from plasma, have now been determined. The LA-ART treatment contains nanoformulated...

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Identifiers

PMID: 40683956
DOI: 10.1038/s42003-025-08499-6
PMCID: PMC12276314

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