Article
Antimicrobial and anti-inflammatory activities of three chensinin-1 peptides containing mutation of glycine and histidine residues.
Scientific reports - 5 Jan 2017
Dong Weibing, Mao Xiaoman, Guan Yue, Kang Yao, Shang Dejing
Abstract excerpt
The natural peptide chensinin-1 doesnot exhibit its desired biological properties. In this study, the mutant MC1-1 was designed by replacing Gly in the chensinin-1 sequence with Trp. Mutants MC1-2 and MC1-3 were designed based on the MC1-1 sequence to investigate the specific role of His residues. The mutated peptides presented α-helicity in a membrane-mimetic environment and exhibited broad-spectrum...
Topics
- Animals
- Anti-Infective Agents
- Anti-Inflammatory Agents
- Antimicrobial Cationic Peptides
- Gram-Negative Bacteria
- Interleukin-6
- Macrophages
- Mice
- Mutant Proteins
- Mutation
- Peptides