Article
Effect of positive charges in the structural interaction of crabrolin isoforms with lipopolysaccharide.
Journal of peptide science : an official publication of the European Peptide Society - 1 Sept 2020
Cantini Francesca, Luzi Carla, Bouchemal Nadia, Savarin Philippe, Bozzi Argante, Sette Marco
Abstract excerpt
Antimicrobial peptides (AMPs) appear as chemical compounds of increasing interest for their role in killing bacteria and, more recently, for their ability to bind endotoxin (lipopolysaccharide, LPS) that is released during bacterial infection and that may lead to septic shock. This dual role in the mechanism of action can further be enhanced in a synergistic way when two or more AMPs are combined together. Not...
Topics
- Antimicrobial Cationic Peptides
- Escherichia coli
- Lipopolysaccharides
- Magnetic Resonance Spectroscopy
- Microbial Sensitivity Tests
- Models, Molecular
- Mutation
- Protein Binding
- Protein Conformation
- Wasp Venoms
