Article
A de novo-designed antimicrobial peptide with activity against multiresistant Staphylococcus aureus acting on RsbW kinase.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2013
Dangel Alexandra, Ackermann Nikolaus, Abdel-Hadi Omar, Maier Richard, Önder Kamil, Francois Patrice, Müller Carsten W, Pané-Farré Jan, Engelmann Susanne, Schrenzel Jacques, Heesemann Jürgen, Lindermayr Christian
Abstract excerpt
Antimicrobial peptides are a promising complement to common antibiotics, development of resistance to which is a growing problem. Here we present a de novo-designed peptide, SP1-1 (RKKRLKLLKRLL-NH2), with antimicrobial activity against multiresistant Staphylococcus aureus (minimal inhibitory concentration: 6.25 μM). Elucidation of the mode of action of this peptide revealed a strong interaction with RsbW kinase...
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