Investigation of the mutated antimicrobial peptides to inhibit ACE2, TMPRSS2 and GRP78 receptors of SARS-CoV-2 and angiotensin II type 1 receptor (AT1R) as well as controlling COVID-19 disease.

Abstract excerpt

SARS-CoV-2 is a global problem nowadays. Based on studies, some human receptors are involved in binding to SARS-CoV-2. Thus, the inhibition of these receptors can be effective in the treatment of Covid-19. Because of the proven benefits of antimicrobial peptides (AMPs) and the side effects of chemical drugs, they can be known as an alternative to recent medicines. RCSB PDB to obtain PDB id, StraPep and PhytAMP to...

Topics

• Angiotensin-Converting Enzyme 2
• Endoplasmic Reticulum Chaperone BiP
• Humans
• SARS-CoV-2
• Molecular Docking Simulation
• Serine Endopeptidases
• COVID-19 Drug Treatment
• COVID-19
• Antimicrobial Peptides