Lineage-specific mutational clustering in protein structures predicts evolutionary shifts in function.

Abstract excerpt

Motivation: Spatially clustered mutations within specific regions of protein structure are thought to result from strong positive selection for altered protein functions and are a common feature of oncoproteins in cancer. Although previous studies have used spatial substitution clustering to identify positive selection between pairs of proteins, the ability of this approach to identify functional shifts in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Computational Biology
• Share to Evolution, Molecular