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Article

Correlated evolution of nearby residues in Drosophilid proteins.

PLoS genetics - 1 Feb 2011

Callahan Benjamin, Neher Richard A, Bachtrog Doris, Andolfatto Peter, Shraiman Boris I

Abstract excerpt

Here we investigate the correlations between coding sequence substitutions as a function of their separation along the protein sequence. We consider both substitutions between the reference genomes of several Drosophilids as well as polymorphisms in a population sample of Zimbabwean Drosophila melanogaster. We find that amino acid substitutions are "clustered" along the protein sequence, that is, the frequency of...

Topics

Amino Acid Substitution
Animals
Drosophila Proteins
Drosophila melanogaster
Evolution, Molecular
Multigene Family
Mutation
Phylogeny
Selection, Genetic

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21383965
DOI: 10.1371/journal.pgen.1001315
PMCID: PMC3044683

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