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Article

Use of reprogrammed cells to identify therapy for respiratory papillomatosis.

The New England journal of medicine - 27 Sept 2012

Yuan Hang, Myers Scott, Wang Jingang, Zhou Dan, Woo Jennifer A, Kallakury Bhaskar, Ju Andrew, Bazylewicz Michael, Carter Yvonne M, Albanese Christopher, Grant Nazaneen, Shad Aziza, Dritschilo Anatoly, Liu Xuefeng, Schlegel Richard

Abstract excerpt

A patient with a 20-year history of recurrent respiratory papillomatosis had progressive, bilateral tumor invasion of the lung parenchyma. We used conditional reprogramming to generate cell cultures from the patient's normal and tumorous lung tissue. Analysis revealed that the laryngeal tumor cells contained a wild-type 7.9-kb human papillomavirus virus type 11 (HPV-11) genome, whereas the pulmonary tumor cells...

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Identifiers

PMID: 23013073
DOI: 10.1056/NEJMoa1203055
PMCID: PMC4030597

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