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Article

FGFR1 Oncogenic Activation Reveals an Alternative Cell of Origin of SCLC in Rb1/p53 Mice.

Cell reports - 17 Mar 2020

Ferone Giustina, Song Ji-Ying, Krijgsman Oscar, van der Vliet Jan, Cozijnsen Miranda, Semenova Ekaterina A, Adams David J, Peeper Daniel, Berns Anton

Abstract excerpt

Fibroblast growth factor receptor 1 (FGFR1) is frequently amplified in human small-cell lung cancer (SCLC), but its contribution to SCLC and other lung tumors has remained elusive. Here, we assess the tumorigenic capacity of constitutive-active FGFR1 (FGFR1K656E) with concomitant RB and P53 depletion in mouse lung. Our results reveal a context-dependent effect of FGFR1K656E: it impairs SCLC development from...

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Identifiers

PMID: 32187553
DOI: 10.1016/j.celrep.2020.02.052
PMCID: PMC7090386

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