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Article

Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells

19 Nov 2012

Abstract excerpt

The combination of irradiated fibroblast feeder cells and Rho kinase inhibitor, Y-27632, conditionally induces an indefinite proliferative state in primary mammalian epithelial cells. These conditionally reprogrammed cells (CRCs) are karyotype-stable and nontumorigenic. Because self-renewal is a recognized property of stem cells, we investigated whether Y-27632 and feeder cells induced a stem-like phenotype. We...

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PMID: 23169653
DOI: 10.1073/pnas.1213241109

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