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Article

The Early-Onset Myocardial Infarction Associated PHACTR1 Gene Regulates Skeletal and Cardiac Alpha-Actin Gene Expression.

PloS one - 1 Jan 2015

Kelloniemi Annina, Szabo Zoltan, Serpi Raisa, Näpänkangas Juha, Ohukainen Pauli, Tenhunen Olli, Kaikkonen Leena, Koivisto Elina, Bagyura Zsolt, Kerkelä Risto, Leosdottir Margret, Hedner Thomas, Melander Olle, Ruskoaho Heikki, Rysä Jaana

Abstract excerpt

The phosphatase and actin regulator 1 (PHACTR1) locus is a very commonly identified hit in genome-wide association studies investigating coronary artery disease and myocardial infarction (MI). However, the function of PHACTR1 in the heart is still unknown. We characterized the mechanisms regulating Phactr1 expression in the heart, used adenoviral gene delivery to investigate the effects of Phactr1 on cardiac...

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Identifiers

PMID: 26098115
DOI: 10.1371/journal.pone.0130502
PMCID: PMC4476650

Genes

PHACTR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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