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Article

Suppression of Rap1 impairs cardiac myofibrils and conduction system in zebrafish.

PloS one - 1 Jan 2012

Dong Wei, Yang Zhenglin, Yang Fan, Wang Jialiang, Zhuang Yan, Xu Chongren, Zhang Bo, Tian Xiao-Li, Liu Dong

Abstract excerpt

Numerous studies have revealed that Rap1 (Ras-proximate-1 or Ras-related protein 1), a small GTPase protein, plays a crucial role in mediating cAMP signaling in isolated cardiac tissues and cell lines. However, the involvement of Rap1 in the cardiac development in vivo is largely unknown. By injecting anti-sense morpholino oligonucleotides to knock down Rap1a and Rap1b in zebrafish embryos, and in combination...

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Identifiers

PMID: 23226434
DOI: 10.1371/journal.pone.0050960
PMCID: PMC3511394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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